Some products that contain yohimbine / Rauwolscine in various forms:

-USPLabs OxyElite Pro

-Empyrean Lipo-Sear

-PrimaForce Yohimbine HCL (pure yohimbine HCL)

-IForce Adipoxil

-VPX Clenbutrx Hardcore

-Nutrex Lipo6 Black

-MAN Swagger

-BPI Rx6

-NRG-X Labs Alpha MaXX Black Label

Yohimbine is an alkaloid (you don’t really need to know what this is, the classification is murky and some experts disagree) with stimulant and aphrodisiac properties. We’re going to focus on the stimulant — and possibly, adipolytic, as in the title — properties. As a quick aside, the aphrodisiac properties are anecdotal only. (But by all means, if this peaks your interest, give it a whirl :lol: )

Adipolytic refers to the breakdown of adipose (fatty) tissue. When we’re trying to lose fat, this is our primary aim. Adipolysis is governed by the adrenergic receptors, of which there are two: alpha- and beta-receptors (there are also sub-types of each). Yohimbine antagonizes the alpha-2 receptors.

Agonizing (activating) the alpha-2 receptors — the opposite of what yohimbine does — inhibits the release of norepinephrine. Norepinephrine (NE) is the body’s primary endogenous thermogenic hormone. Ephedrine, for example, stimulates NE release, and most of us remember how effective it was. The problem with the catecholamines, norepinephrine and epinephrine, is that they are non-selective agonists of the alpha- and beta-receptors. So when catecholamines are secreted (during the fight-or-flight ANS response, after ingesting ephedrine or other related compounds, etc.) they actually function as their own negative feedback loop by binding to the alpha-2 receptor: they turn themselves off. This may sound counterintuitive, but the body is rife with these loops and they function much like a thermostat would function as a means of auto-regulation.

Agonizing the alpha-2 receptors also has another, uglier function: the inhibition of adipolysis (in adipose tissue, obviously). So, in plain English, binding to the alpha-2 receptors turns off fat-loss.

It is possible to elevate norepinephrine levels to the extent that they override this shutoff mechanism and adipolysis occurs; this is exactly what high doses of ephedrine do. Still, it’s like trying to accelerate a car with the brakes partially engaged: regardless of the degree of elevation of NE levels, binding to the alpha-2 receptor will still occur.

So yohimbine, by antagonizing the alpha-2 receptors, binds to them with no effect, but blocks or dampens agonist-mediated responses. In other words, it prevents norepinephrine (or anything else) from binding to the alpha-2 receptors; it does not allow the alpha-2 receptors to stop fat-loss (adipolysis) from occurring.

Supplemental yohimbine allows you to accelerate the (fat-loss) car without having your foot on the brake. In fact, to visualize the antagonistic action of yohimbine, think of a rock lodged under the break pedal (the alpha-2 receptor) and your foot, an alpha-2 agonist, trying to depress the pedal — it’s not going to happen.

Some notes:

-You need a high dose of yohimbine for the benefits to occur, higher than what is commonplace. Something like 0.09 mg/lb of body weight, which would be 20mg for a 220 lb person. Studies using lower doses were not as compelling. (An easy rule of thumb is 1mg per 10 lbs of body weight)

-Yohimbine, combined with other stimulants, can further elevate your heart rate.

-Yohimbine can cause anxiety and thus should not be used by individuals prone to panic attacks or those suffering from stress-related disorders.

-Insulin completely negates yohimbine’s effectiveness, so it should be taken first thing upon awakening or between meals.

-Adipose tissue is poorly vascularized, i.e., it has poor blood flow. Alpha receptors also decrease blood flow, intensifying this problem; and, wouldn’t you know it, alpha receptors are most prevalent in abdominal tissue and gluteofemoral tissue in males and females, respectively. “Stubborn areas,” in terms of fat-loss, can be attributed to this disparity, as can the traditional “apple” (male) and “pear” (female) fat deposition patterns. Anyone who has ever dieted into contest shape has seen this deposition effect in reverse: abdominals/lower back will be the last places to lose fat in men and hips and thighs in women. Again, antagonizing alpha-2s with yohimbine can help increase blood flow to these problem sites, possibly increasing fatty acid mobilization (and thus ultimately, disposal).

-Yohimbine has a very short half-life (1-2 hours). Other metabolites are said to have longer half-lives, but insulin still negates their effects, so it is best used in short-term (i.e., the next 45 minutes) applications.

-Alpha-yohimbine (Rauwolscine) is a steroisomer of yohimbine that may have a greater affinity for the alpha-2 receptors than yohimbine. Furthermore, it may present with less “side” effects than yohimbine — less tachycardia, blood pressure elevation, and anxiety. Rauwolscine may account for the recent success of the fat burner OxyElite Pro from USPLabs.

-If this wasn’t clear, the effective form is Yohimbine HCL, not yohimbe bark or similar.

Two promising studies:

-McCarty MF. Pre-exercise administration of yohimbine may enhance the efficacy of exercise training as a fat loss strategy by boosting lipolysis. Med Hypotheses, 2002 Jun;58(6):491-5

-Ostojic SM. Yohimbine: the effects on body composition and exercise performance in soccer players. Res Sports Med, 2006 Oct-Dec;14(4):289-99

Some products that contain yohimbine / Rauwolscine in various forms:

-USPLabs OxyElite Pro

-Empyrean Lipo-Sear

-PrimaForce Yohimbine HCL (pure yohimbine HCL)

-IForce Adipoxil

-VPX Clenbutrx Hardcore

-Nutrex Lipo6 Black

-MAN Swagger

-BPI Rx6

-NRG-X Labs Alpha MaXX Black Label