Continued from the original press release from Best Price Nutrition...
Before coffee beans are roasted they are fresh and green. Brewed coffee has been roasted, hence it is brown (maillard reaction) and more importantly approximately 90% of the of the chlorogenic acid is lost in the process. Chlorogenic acid is an antioxidant and the active ingredient in Green Coffee Bean Extract responsible for the purported weight loss and anti-hypertensive effects.
For a 200mg dose of Svetol® Green Coffee Bean Extract that breaks down to:
-90mg CGA (Chlorogenic Acid)
-30mg 5-CQA (Caffeoylquinic acid)
The internet is riddled with articles referencing various studies on Green Coffee Bean Extract (GCA®, Svetol®, Chlorogenic Acid, etc…). Some articles are relevant, some are hyperbolic, some are filled with anecdotes, and many are simply repeating what others have written.
In August of 2010 a review of current data and clinical trials on green coffee bean extract was published in the Gastroenterology Research and Practice Journal. In this review the reviewers analyzed the available data on green coffee bean extract. The criteria employed were such that the reviewers only included randomized, double-blind, and placebo-controlled studies only (correctly so). Also as part of the criteria the studies had to test the efficacy of green coffee bean extract for weight loss in obese or overweight people. Based on the data from the three studies that met the above criteria the reviewers concluded that green coffee bean extract can promote weight loss in obese or overweight people. That being said the reviewers did state that “more rigorous trials with longer duration are needed to assess the efficacy and safety of green coffee bean extract as a weight loss supplement.”
Since this review a few other studies have been conducted on green coffee bean extract for the purpose of weight loss. The most commonly referred to study of late on green coffee bean extract was conducted by Joe Vinson, Ph.D., and colleagues on 16 overweight or obese people.
The specifics of the randomized, double-blind, placebo-controlled, linear dose, crossover study were as follows:
-Participants were 22-26 years old
-According to the researchers all of the participants had their diet and exercise monitored for the duration of the study and both remained consistent throughout
-The green coffee bean extract used in the study was GCA®(trade name for green coffee extract owned by Applied Food Sciences, Inc.) and contained 45.9% chlorogenic acids
-The duration of the study was 22 weeks however there were 2 – 2 week washout periods in the study, therefore it was technically 18 weeks and can be broken down into 3 – 6 week periods where the participants alternated between the high dose (3 x 350mg GCA®), low dose (2 x 350mg GCA®), and placebo
-Average weight loss was 17.5 pounds during the study
-This equates to a 10.5% decrease in total body weight and a 16% decrease in body fat
Those are some pretty impressive results however the method for measuring body fat employed a SFB7 which is a single channel, tetra polar bioimpedance spectroscopy (BIS) device that scans for the estimation of body composition in healthy individuals. These are not exactly the gold standard in measuring body fat levels. Independent of that the weight loss results were impressive and lead us to the question of who can benefit most from supplementing with green coffee bean extract? Based on the data available it is not for the athlete or in shape person looking to lose those last few pounds of body fat covering those six pack abs as the purported effects (blood sugar control) are not rate limiting for those individuals. Rather overweight or obese individuals can likely benefit from it. Best Price Nutrition would like to see more rigorous human trials in the future to validate the current research results, however this is promising.
The data suggest green coffee bean extract can help with mild hypertension. Specifically a double-blind, placebo-controlled study was conducted.
The specifics were as follows:
-117 male participants with mild hypertension
-The study duration was one month
-Participants were give green coffee bean extract (~30% CGA) at 46 mg, 93 mg, or 185 mg daily (or placebo)
-The results were dose-related which means that the greater the dose, the greater the improvement observed. At 185mg a decrease of -5.6+/-4.2 mmHg from the baseline
Green Coffee Bean Extract is purported to help treat mild hypertension, diabetes via suppressing excess blood sugar, and melt away body fat in overweight individuals. Specifically the mechanism of action in terms of weight loss is inhibition of glucose-6-phosphatase (which is an enzyme that plays a key role in regulating of blood sugar levels). This in turn can lead to inhibiting the absorption of some calories. Controlling blood sugar levels is one oof the keys in fighting weight gain and obesity
Research has consistently demonstrated Green Coffee Bean Extract to be safe for humans. The caffeine content is very low (less than 10% in most and less than 2% in products using Svetol®). Green Coffee Bean Extract has not been studied in pregnant or nursing women. Since this is a weight loss product it is not something a pregnant woman should take anyways rather the focus should be on a nutrient dense diet. In absence of research specifically on women nursing and the fact that many will take it despite the lack of research; we recommend breast feeding or pumping extra before taking Green Coffee Bean Extract. This will help avoid passing anything into your milk. Also it is always smart to check with your physician before using it while nursing.
Onakpoya I, Terry R, Ernst E. "The use of green coffee extract as a weight loss supplement: a systematic review and meta-analysis of randomised clinical trials." Gastroenterol Res Pract. 2011;2011. pii: 382852.
Shimoda H, Seki E and Aitani M. Inhibitory effect of green coffee bean extract on fat accumulation and body weight gain in mice. BMC Complementary and Alternative Medicine 2006;6:9
Arion WJ, Canfield WK, Ramos FC, et al. Chlorogenic acid and hydroxynitrobenzaldehyde: new inhibitors of hepatic glucose 6-phosphatase. Arch Biochem Biophys . 1997;339:315–322.
Van Dam RM, Feskens EJ. Coffee consumption and risk of type 2 diabetes mellitus. Lancet . 2002;360:1477–1478.
Ranheim T, Halvorsen B. Coffee consumption and human health--beneficial or detrimental?--Mechanisms for effects of coffee consumption on different risk factors for cardiovascular disease and type 2 diabetes mellitus. Mol Nutr Food Res . 2005;49:274-84
Vinson JA, Burnham BR, Nagendran MV. Randomized, double-blind, placebo-controlled, linear dose, crossover study to evaluate the efficacy and safety of a green coffee bean extract in overweight subjects. Diabetes Metab Syndr Obes. 2012;5:21-7.
Kozuma K, Tsuchiya S, Kohori J et al. Antihypertensive effect of green coffee bean extract on mildly hypertensive subjects. Hypertens Res . 2006;28:711-8.
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