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What is ACP-105?

Is ACP-105 The Ultimate Recomp SARM?

ACP-105 is a Selective Androgen Receptor Modulator or SARM. It was originally developed by Acadia Pharmaceuticals to help treat degenerative conditions like osteoporosis and muscle wasting.

Unlike older performance enhancers ACP-105 was designed to be "selective" meaning it targets the androgen receptors in your muscles and bones while trying to avoid receptors in organs like the prostate or liver.

ACP-105 doesn't come from a plant or natural food source, its a synthetic research chemical which was created in a lab specifically for medical research. ACP-105 is not approved by the FDA for human use and is currently sold primarily through "research chemical" websites rather than supplement stores.

Is ACP-105 a Sarm, Steroid or Peptide?

ACP-105 is a SARM, a Selective Androgen Receptor Modulator. It's NOT a steroid. While steroids are blunt instruments that affect the entire body and often convert to estrogen or DHT, SARMS like ACP-105 are non-steroidal and designed for tissue selectivity. It's also NOT a peptide as peptides are chains of amino acids that usually signal the body to release hormones like Growth Hormone for example. ACP-105 works directly on androgen receptors instead. 

ACP-105 Purported Benefits

  • Lean Muscle Gain: Helps the body stay in an anabolic state making it easier to build muscle even in a caloric deficit
  • Enhanced Fat Loss: By increasing metabolic activity and muscle mass it can help with a "recomp" ie losing fat and gaining muscle at the same time.
  • Strength Increases: Users report significant strenght increases in the first 2-3 weeks.
  • Cognitive Support: Early animal studies suggested ACP-105 might reduce anxiety and improve memory though this hasn't been proven in humans.
  • Faster Recovery: Reduces the amount of downtime needed between grueling workouts. 

Does ACP-105 Have Side Effects?

ACP-105 while considered fairly mild does have potential side effects as it does interact with your hormonal system. Potential side effects include testosterone suppression, liver toxicity, headaches and nausea, vision changes and potential drops in your HDL cholesterol levels. 

Who May Benefit From ACP-105?

In a clinical sense ACP-105 is intended for patients suffering from muscle wasting or bone density loss however it may also appeal to some athletes and those in the fitness world including...

  • Cutters: People looking to maintain muscle mass while dropping fat
  • Beginners To SARMS: Those who want to experiment with performance enhancers but want something less aggressive than say RAD-140
  • Athletes In Weight Class Sports: Because it provides dry gains ie no water retention. It helps athletes get stronger without moving up a weight class.

*It's important to note ACP-105 is currently on the WADA Prohibited List. If you compete in drug tested sports this will result in a ban.

Which Prohormones Are Most Similar to ACP-105?

1-Andro Prohormones (1-Testosterone, Chosen1, LG Sciences 1-Andro)

Why It's Similar: Like ACP-105, 1-Andros do not aromatize into estrogen which means you get dry muscle gains without bloating or man boobs.

The Effect: It focuses on muscle hardness and strength. Users report a similar recomp effect where they lose fat while tightening up muscle tissue. 

Epiandros (Winstrol, Dymethazine, Superstrol7)

Why It's Similar: ACP105 is often used in cutting phases to stay strong while leaning out. Epiandros are designed specifically for lean mass and high muscle definition.

The Effect: It increases protein synthesis and nitrogen retention while preventing water weight, similar to the dry look that ACP-105 provides. 

What Reddit Is Saying About ACP-105

I ran ACP three times thus far at a dose of 10mg per day. Strength has always gone up and only side effect has been a mild headache. 

On my first cycle of ACP105, its an excellent preworkout androgen and spikes fast, increases strength and makes me feel super good metnally. 

I've taken it along with MK677, had popping veins and more strenght and endurance. 

Wrapping Up

ACP105 is a powerful research chemical that offers a middle ground between natty lifting and harsh steroids. Because it lacks long term human clinical trials anyone using it is essentially acting as their own test subject. That said it does appear to offer some potential benefits to athletes and weightlifters. 

Feb 16th 2026

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